The type of seeder cells determines the efficiency of germinal center reactions
نویسندگان
چکیده
منابع مشابه
The type of seeder cells determines the efficiency of germinal center reactions.
During humoral immune responses some germinal centers (GCs) develop very well and give rise to a large number of high affinity antibody producing plasma cells. Other GC reactions develop poorly, somatic mutation is reduced, and the output production is practically absent. This led to the hypothesis that two classes of GCs exist, and that GCs show an all-or-none behaviour. We investigate the rol...
متن کامل. bi o - ph ] 3 S ep 2 00 2 The type of seeder cells determines the efficiency of germinal center reactions
We discuss the origin of two classes of germinal centers that have been observed during humoral immune responses: Some germinal centers develop very well and give rise to a large number of high affinity antibody producing plasma cells. Other germinal center reaction are very weak and the output production is practically absent. We propose an explanation for this nearly all-or-none behavior of g...
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ژورنال
عنوان ژورنال: Bulletin of Mathematical Biology
سال: 2004
ISSN: 0092-8240
DOI: 10.1016/j.bulm.2003.08.003